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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
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Related Experiment Video

Updated: Feb 7, 2026

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
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A lncRNA-like Role for LINE1s in Development.

Drew D Honson1, Todd S Macfarlan1

  • 1The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA.

Developmental Cell
|July 18, 2018
PubMed
Summary

Long Interspersed Element 1 (LINE1) transposable elements regulate gene expression. This function is crucial for embryonic stem cell self-renewal and early development.

Area of Science:

  • Genomics
  • Molecular Biology
  • Developmental Biology

Background:

  • Transposable elements (TEs) are mobile genetic sequences that shape genome evolution.
  • LINE1 elements are abundant TEs in mammalian genomes with poorly understood regulatory roles.
  • Gene expression and chromatin landscapes are influenced by TEs.

Purpose of the Study:

  • To investigate the non-canonical functions of LINE1 elements.
  • To determine the role of LINE1 in regulating gene expression.
  • To understand LINE1's contribution to embryonic stem cell (ESC) self-renewal and preimplantation development.

Main Methods:

  • Analysis of LINE1 expression and localization in ESCs.
  • Functional assays to assess the impact of LINE1 on gene regulation.

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  • Studies on ESC self-renewal and differentiation potential.

    • Main Results:

    • LINE1 elements exhibit lncRNA-like functions.
    • LINE1 regulates specific gene networks essential for ESC pluripotency.
    • LINE1 activity is critical for successful preimplantation development.

    Conclusions:

    • LINE1 elements are not merely "junk DNA" but play active regulatory roles.
    • LINE1-mediated gene regulation is vital for maintaining ESC identity.
    • Understanding LINE1 functions offers insights into developmental processes and potential therapeutic targets.