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FMRFamide suppresses kappa opiate induced feeding in the mouse
Peptides
|September 1, 1985
Abstract:
Intracerebroventricular administration of 0.01-1.0 micrograms of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) to mice suppressed feeding induced by the specific kappa opiate agonist, U-50, 488H. This suggests that FMRFamide, or FMRFamide-like neuropeptides, may have a role in the control of kappa opioid mediated feeding in the mouse.
Insights
The peptide FMRFamide suppresses feeding behavior in mice that is induced by kappa opiate agonists. This indicates a role for FMRFamide-like neuropeptides in regulating kappa opioid-mediated feeding responses.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Opioid agonists, particularly kappa-selective ones, are known to stimulate feeding behavior.
- Neuropeptides play crucial roles in modulating various physiological processes, including appetite and feeding.
Purpose of the Study:
- To investigate the potential role of the neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) in modulating kappa opioid-induced feeding in mice.
Main Methods:
- Intracerebroventricular administration of varying doses (0.01-1.0 micrograms) of FMRFamide to mice.
- Assessment of the effect of FMRFamide on feeding behavior induced by the kappa opiate agonist U-50,488H.
Main Results:
- FMRFamide administration significantly suppressed feeding behavior in mice challenged with U-50,488H.
- The observed suppression occurred in a dose-dependent manner.
Conclusions:
- FMRFamide and related neuropeptides may function as endogenous regulators of kappa opioid-mediated feeding pathways.
- These findings suggest a potential neurochemical interaction between FMRFamide signaling and the opioid system in appetite control.