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In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa

Wei Yee Chan1, Elizabeth E Hickey1, Manouchehr Khazandi1

  • 1Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Mudla Wirra Rd, Roseworthy, SA 5371, Australia.

Comparative Immunology, Microbiology and Infectious Diseases
|July 19, 2018
PubMed

Insights

Monensin shows promise for treating canine ear infections caused by Gram-positive bacteria, including multidrug-resistant strains. This study evaluated its effectiveness, offering a potential solution for antimicrobial stewardship in veterinary medicine.

Area of Science:

  • Veterinary Medicine
  • Microbiology
  • Pharmacology

Background:

  • Antimicrobial resistance is a growing concern in veterinary medicine.
  • Multidrug-resistant infections in dogs necessitate alternative treatment strategies.
  • Repurposing older drugs not critical for human medicine is a key approach to antimicrobial stewardship.

Purpose of the Study:

  • To determine the antimicrobial activity of monensin against canine otitis isolates.
  • To evaluate monensin's potential as a therapeutic agent for canine ear infections.

Main Methods:

  • Minimal inhibitory concentration (MIC) of monensin was determined for 111 bacterial and yeast canine otitis isolates.
  • Microdilution methodology was employed following Clinical Laboratory Standards Institute (CLSI) guidelines.

Main Results:

  • Monensin demonstrated effectiveness against all Gram-positive bacteria, including multidrug-resistant staphylococcal strains, with MICs between 1-4 μg/ml.
  • Monensin exhibited no antimicrobial activity against Gram-negative bacteria or yeast isolates.

Conclusions:

  • Monensin is a viable candidate for treating Gram-positive bacterial infections in canine otitis.
  • Monensin has potential for inclusion in otic formulations for veterinary use.
Keywords:
Antimicrobial susceptibilityCanineMICMonensinOtitis externa

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