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Decreased functional connectivity within the default-mode network in acute brainstem ischemic stroke.
Liang Jiang1, Wen Geng1, Huiyou Chen1
1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
European Journal of Radiology
|July 19, 2018
Summary
Acute ischemic brainstem stroke impairs default-mode network (DMN) connectivity, particularly in the right mPFC and precuneus. This reduced connectivity correlates with higher homocysteine levels, offering insight into cognitive dysfunction after stroke.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Ischemic stroke in the brainstem can lead to cognitive dysfunction.
- The default-mode network (DMN) plays a crucial role in cognitive functions.
- Understanding DMN integrity is vital for patients with brainstem stroke.
Purpose of the Study:
- To investigate the default-mode network (DMN) integrity in patients with acute ischemic brainstem stroke.
- To explore the relationship between DMN connectivity and clinical variables using independent component analysis (ICA).
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) was performed on 21 patients with acute ischemic brainstem stroke and 25 healthy controls.
- Independent component analysis (ICA) was used to extract anterior and posterior components of the DMN.
- Pearson correlation analyses examined the association between DMN connectivity and clinical factors.
Main Results:
- Patients with brainstem stroke exhibited significantly reduced functional connectivity in the right medial prefrontal cortex (mPFC) and right precuneus compared to controls.
- Hypoconnectivity in these DMN regions was negatively correlated with elevated homocysteine levels in stroke patients.
- These findings were observed after adjusting for age, sex, and education.
Conclusions:
- Decreased functional connectivity within the DMN is a key finding in patients with acute brainstem stroke.
- This study provides novel insights into the neural mechanisms underlying cognitive impairment after brainstem ischemic insults.
- The results highlight the importance of DMN integrity in the context of brainstem stroke recovery and cognitive function.
Keywords:
Default-mode networkFunctional connectivityIndependent component analysisIschemic strokeResting-state fMRIMore Related Videos
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