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Calorimetry is a technique used to measure the amount of heat involved in a chemical or physical process or to measure the heat transferred to or from a substance. The heat is exchanged with a calibrated and insulated device called the calorimeter. Calorimetry experiments are based on the assumption that there is no heat exchange between the insulated calorimeter and the external environment. The well-insulated calorimeters prevent the transfer of heat between the calorimeter and its external...
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When objects at different temperatures are placed in contact with each other but isolated from everything else, they attain thermal equilibrium. A container that prevents heat transfer in or out is called a calorimeter, and the use of a calorimeter to make measurements is called calorimetry. Generally, these measurements involve heat or specific heat capacity. The term "calorimetry problem" is used for any problem where the specified objects are thermally isolated from their...
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Calorimeters are useful to determine the heat released or absorbed by a chemical reaction. Coffee cup calorimeters are designed to operate at constant (atmospheric) pressure and are convenient to measure heat flow (or enthalpy change) accompanying processes that occur in solution at constant pressure. A different type of calorimeter that operates at constant volume, colloquially known as a bomb calorimeter, is used to measure the energy produced by reactions that yield large amounts of heat and...
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Microsoft Excel is a cornerstone tool for data analysis and statistical operations, offering a wide array of functionalities to manage, analyze, and visualize data efficiently. Recognized for its versatility, Excel facilitates the performance of basic to complex statistical operations, serving as an indispensable asset for analysts, researchers, and students alike. Excel's significance in data analysis emanates from its spreadsheet environment, where data can be organized in rows and...
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Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
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CalR: A Web-Based Analysis Tool for Indirect Calorimetry Experiments.

Amir I Mina1, Raymond A LeClair2, Katherine B LeClair1

  • 1Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

Cell Metabolism
|July 19, 2018
PubMed
Summary
This summary is machine-generated.

CalR is a new web-based tool that simplifies the analysis of indirect calorimetry experiments for physiological energy balance. It enhances data interpretation, reproducibility, and efficiency in metabolic research.

Keywords:
ANCOVACLAMSbiostatisticsenergy balanceenergy expenditurefood intakeindirect calorimetrymetabolic phenotypingmetabolismreproducibility

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Area of Science:

  • Physiology
  • Bioinformatics
  • Metabolic Research

Background:

  • Indirect calorimetry is crucial for measuring physiological energy balance.
  • Analyzing indirect calorimetry data can be complex and time-consuming.
  • Standardized, reproducible analysis methods are needed in metabolic research.

Purpose of the Study:

  • To introduce CalR, a web-based tool for analyzing indirect calorimetry experiments.
  • To simplify data import, plotting, and statistical analysis.
  • To enhance transparency, rigor, and reproducibility in metabolic research.

Main Methods:

  • CalR is a web-based application accessible at CalRapp.org.
  • It utilizes generalized linear models (including ANOVA and ANCOVA) for flexible data interpretation.
  • The tool supports standardized output file generation for data sharing and re-evaluation.

Main Results:

  • CalR streamlines the import of raw data and generation of plots.
  • It assists in selecting appropriate statistical tests for diverse experimental designs.
  • Standardized output files facilitate data sharing and reproducibility.

Conclusions:

  • CalR offers a user-friendly and efficient platform for analyzing indirect calorimetry data.
  • The tool promotes transparency and reproducibility in metabolic research.
  • CalR is expected to become a standard tool for the scientific community.