Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

68.2K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
68.2K
What is the Endocrine System?00:46

What is the Endocrine System?

420.8K
The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
420.8K
The Endocrine System01:29

The Endocrine System

1.4K
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.4K
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

14.2K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
14.2K
Structures of the Endocrine System00:59

Structures of the Endocrine System

12.2K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
12.2K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

7.3K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathogen detection in central nervous system infections: moving metagenomic sequencing closer to clinical practice.

BMC infectious diseases·2026
Same author

Developing the evidence and associated service models to improve pain management in older people living with frailty: a synopsis of the POPPY mixed method, co-design study.

Health and social care delivery research·2026
Same author

Enabling health and maintaining independence for older people at home: the 'HomeHealth' Randomised Controlled Trial.

Health technology assessment (Winchester, England)·2026
Same author

Teriparatide Plus Zoledronic Acid for Osteogenesis Imperfecta: A Randomized Clinical Trial.

JAMA·2026
Same author

How feasible is self-monitoring for the management of prehypertension? The REVERSE study.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same author

Projected trends in frailty prevalence and associated health service use and costs in the over-50s in England, 2025 to 2040: a simulation modelling study.

Age and ageing·2026

Related Experiment Video

Updated: Feb 7, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.1K

Frailty and the endocrine system.

Andrew Clegg1, Zaki Hassan-Smith2

  • 1Academic Unit of Elderly Care and Rehabilitation, University of Leeds, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.

The Lancet. Diabetes & Endocrinology
|July 19, 2018
PubMed
Summary
This summary is machine-generated.

This review highlights the endocrine system

More Related Videos

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

617
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K

Related Experiment Videos

Last Updated: Feb 7, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.1K
Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

617
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K

Area of Science:

  • Endocrinology and Geriatric Medicine

Background:

  • Frailty is a complex condition marked by diminished physiological reserves and increased vulnerability.
  • The endocrine system plays a crucial role in frailty due to its intricate connections with the brain, immune system, and muscles.

Purpose of the Study:

  • To review the evidence implicating the endocrine system in the pathogenesis of frailty.
  • To explore potential therapeutic targets within the endocrine system for frailty management.

Main Methods:

  • Systematic review of existing literature on endocrine mechanisms in frailty.
  • Analysis of studies focusing on the hypothalamic-pituitary axis, vitamin D, insulin resistance, and thyroid hormones.

Main Results:

  • The hypothalamic-pituitary axis is central to frailty through dysregulated glucocorticoid, IGF-1, and androgen signaling.
  • Vitamin D deficiency and insulin resistance are implicated in frailty development.
  • The role of thyroid hormones in frailty pathogenesis remains unclear.

Conclusions:

  • Aberrant endocrine signaling, particularly via the hypothalamic-pituitary axis, contributes significantly to frailty.
  • Muscle mass loss and reduced mobility are key consequences.
  • Future research should target endocrine pathways for biomarkers and novel treatments for frailty.