Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.7K
The Thyroid Gland01:23

The Thyroid Gland

7.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.7K
Aging01:26

Aging

714
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
714
Quantitative Aspects of Drug-Receptor Interaction01:30

Quantitative Aspects of Drug-Receptor Interaction

1.8K
The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
1.8K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.9K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The SINTER study: a recall-by-genotype design with multidimensional musculoskeletal phenotyping across internal-medicine outpatient clinics.

European journal of epidemiology·2026
Same author

Determinants of pro- and anti-inflammatory cytokine profiles across populations.

BMC medicine·2026
Same author

Clinical Features, CT Imaging Decisions and Yield by Age in Adults With Abdominal Pain in the Emergency Department.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2026
Same author

Determinants of Immunoglobulin-G N-Glycan Patterns in the Aging General Population.

Allergy·2026
Same author

Natural history of thyroid function in ageing: an individual participant data analysis of 137 488 participants from 31 prospective cohort studies.

The lancet. Diabetes & endocrinology·2026
Same author

Navigating Thyroid Hormone Deprescribing in Older Adults.

JAMA·2026
Same journal

Weight management in China: integrating mental health into routine obesity care.

The lancet. Diabetes & endocrinology·2026
Same journal

Innovation is key to transforming future obesity care.

The lancet. Diabetes & endocrinology·2026
Same journal

Out of touch medical care.

The lancet. Diabetes & endocrinology·2026
Same journal

ADA Scientific Sessions 2026: a line crossed.

The lancet. Diabetes & endocrinology·2026
Same journal

Endocrine-neuropsychological interplay underpinning maternal postpartum depression.

The lancet. Diabetes & endocrinology·2026
Same journal

Intermittent fasting to treat diabetes: time to update clinical practice guidelines.

The lancet. Diabetes & endocrinology·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

778

Clinical aspects of thyroid function during ageing.

Layal Chaker1, Anne R Cappola2, Simon P Mooijaart3

  • 1Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.

The Lancet. Diabetes & Endocrinology
|July 19, 2018
PubMed
Summary
This summary is machine-generated.

As people age, thyroid dysfunction becomes more common but harder to diagnose. This review covers age-related thyroid changes, diagnostic challenges, and treatment for older adults.

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.3K

Related Experiment Videos

Last Updated: Feb 7, 2026

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

778
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.3K

Area of Science:

  • Gerontology
  • Endocrinology
  • Internal Medicine

Background:

  • Global populations are rapidly aging.
  • Thyroid dysfunction is a common disorder in older adults.
  • Diagnosis is complicated by atypical symptom presentation in the elderly.

Purpose of the Study:

  • To review age-related physiological changes in thyroid function.
  • To discuss diagnostic and treatment considerations for thyroid dysfunction in older populations.
  • To explore the links between thyroid function and age-related diseases.

Main Methods:

  • Literature review focusing on aging and thyroid function.
  • Analysis of thyroid function test results in older individuals.
  • Discussion of international treatment guidelines for elderly patients.

Main Results:

  • Thyroid function naturally changes with age.
  • Subclinical and overt thyroid dysfunction are prevalent in the elderly.
  • Thyroid dysfunction is associated with cardiovascular disease, osteoporosis, cognitive impairment, and frailty.

Conclusions:

  • Age-related thyroid dysfunction requires specific diagnostic and management approaches.
  • Understanding these changes is crucial for managing common diseases of old age.
  • Further research is needed to clarify the complex interactions between thyroid function and aging.