Related Experiment Video

Updated: Feb 7, 2026

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
06:03

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

18.3K

Proteogenomic Analysis of Surgically Resected Lung Adenocarcinoma

Michael F Sharpnack1, Nilini Ranbaduge2, Arunima Srivastava3

  • 1Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
|July 19, 2018
PubMed
Abstract

Insights

Integrating RNA and protein data improves lung cancer recurrence prediction. This approach helps identify patients who benefit from adjuvant therapy, addressing a critical need in early-stage non-small cell lung cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Early-stage lung cancer patients often relapse despite surgery.
  • Current adjuvant chemotherapy offers limited benefit (5-8% risk reduction).
  • Improved methods are needed to predict recurrence and identify therapeutic targets.

Purpose of the Study:

  • To develop and validate integrative biomarkers using RNA and protein data.
  • To assess the potential of these biomarkers for predicting recurrence risk in lung adenocarcinoma.
  • To characterize the relationship between mRNA and protein expression and its impact on outcomes.

Main Methods:

  • Generated RNA sequencing and proteomics data from 51 surgically resected non-small cell lung tumors.
  • Correlated molecular data with patient recurrence status.
  • Analyzed the interplay between mRNA and protein measurements.

Main Results:

  • Demonstrated the potential of integrated RNA and protein measurements for predicting recurrence risk.
  • Showcased that mRNA and protein data have independent biological and clinical significance.
  • Identified outcome-specific relationships between mRNA and protein levels in lung adenocarcinoma.

Conclusions:

  • Integrated expression biomarkers can enhance prediction power.
  • Leveraging both mRNA and protein data offers a more robust approach to risk stratification.
  • This strategy can aid in personalizing adjuvant therapy decisions for lung cancer patients.
Keywords:
BiomarkersLung adenocarcinomaNSCLCProteogenomicsProteomics

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

901
Robot Assisted Distal Pancreatectomy with Celiac Axis Resection DP-CAR for Pancreatic Cancer: Surgical Planning and Technique13:56

Robot Assisted Distal Pancreatectomy with Celiac Axis Resection DP-CAR for Pancreatic Cancer: Surgical Planning and Technique

Published on: August 14, 2021

7.3K

Related Concept Videos

Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
7.4K
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
4.8K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
430
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
577
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
526