Related Experiment Video

Updated: Feb 7, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.5K

Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru

Ligia Rios1, Liliana Vásquez1, Mónica Oscanoa1

  • 1Pediatric Oncology Unit, Edgardo Rebagliati Martins Hospital, 490 Domingo Cueto Avenue, Lima 11, Peru.

Journal of Oncology
|July 19, 2018
PubMed

Insights

Advanced parental age increases the risk of childhood retinoblastoma, non-Hodgkin lymphoma, and gonadal germ cell tumors. Higher birth order offers a protective effect against childhood solid tumors.

Area of Science:

  • Pediatric Oncology
  • Epidemiology
  • Genetics

Background:

  • Causes of childhood cancer remain largely unknown.
  • Advanced parental age is a suspected risk factor for childhood cancers.
  • This study investigates the association between parental age and childhood solid tumors.

Purpose of the Study:

  • To examine the relationship between advanced parental age and the risk of specific childhood solid tumors.
  • To assess the influence of maternal and paternal age on cancer development in children.

Main Methods:

  • A hospital-based case-control study was conducted with 310 cases and 620 controls matched for age and gender.
  • The study was performed at Rebagliati Hospital in Lima, Peru.
  • Odds ratios were calculated to compare risks associated with advanced maternal and paternal age, with adjustments for confounding factors.

Main Results:

  • Children of mothers over 35 had a significantly higher risk of retinoblastoma (adjusted OR 1.21).
  • Children of fathers over 35 showed an increased risk of retinoblastoma (OR 1.17), non-Hodgkin's lymphoma (p=0.047), and gonadal germ cell tumors (p=0.04).
  • Increasing parity demonstrated a strong protective effect against childhood solid tumors (p=0.0015).

Conclusions:

  • Advanced parental age is linked to an increased risk of retinoblastoma.
  • Advanced paternal age is associated with higher risks for non-Hodgkin lymphoma and gonadal germ cell tumors.
  • Higher birth order is associated with a reduced risk of developing childhood neoplasms.
Abstract

More Related Videos

Studying Brain Function in Children Using Magnetoencephalography08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K
Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

1.2K

Related Concept Videos

Parental Care00:55

Parental Care

Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
12.8K
Parenting Styles01:27

Parenting Styles

Diana Baumrind's four parenting styles — authoritarian, authoritative, neglectful, and permissive — each influence children's socio-emotional development differently.
Authoritarian Parenting
This style is strict and controlling, with little room for open dialogue. Authoritarian parents demand obedience and often enforce rules with minimal warmth. Children raised this way may lack social skills and initiative, usually comparing themselves to others unfavorably.
Authoritative...
692
Metallic Solids02:37

Metallic Solids

Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.8K
Structures of Solids02:22

Structures of Solids

Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.9K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
475
Relationship with Parents: Attachment01:28

Relationship with Parents: Attachment

Parent-child interactions lay the foundation for how we understand relationships throughout life. These interactions are not uniform across families; instead, they are shaped by a range of environmental, emotional, and behavioral factors unique to each caregiver-child dynamic. Social psychologists study these early relationships to understand how patterns formed in infancy influence social functioning and interpersonal behavior in adulthood.Attachment Theory and Early Relational ModelsJohn...
266