The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers
Robert Szpera1, Nadia Kovalenko1, Kalaiselvi Natarajan1
1Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.
Abstract:
The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the corresponding syn-diastereomer. Both targets were synthesised using an epoxide opening strategy.
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