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Galectin-3 as a Predictor of Left Ventricular Reverse Remodeling in Recent-Onset Dilated Cardiomyopathy

Konstantinos Karatolios1, Georgios Chatzis1, Volker Holzendorf2

  • 1Department of Cardiology, Angiology and Intensive Care, Philipps University Marburg, Marburg, Germany.

Disease Markers
|July 19, 2018
PubMed

Insights

Low galectin-3 levels predict favorable left ventricular reverse remodeling (LVRR) in recent-onset dilated cardiomyopathy (RODCM) patients. This biomarker indicates positive ventricular remodeling, aiding clinical decisions.

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure Research

Background:

  • Galectin-3's association with heart failure outcomes is known.
  • Limited data exists on galectin-3's predictive value for left ventricular reverse remodeling (LVRR) in recent-onset dilated cardiomyopathy (RODCM).

Purpose of the Study:

  • To investigate the clinical usefulness and predictive value of galectin-3 for LVRR in RODCM patients.
  • To determine if baseline galectin-3 levels can predict favorable ventricular remodeling.

Main Methods:

  • 57 RODCM patients were assessed for baseline galectin-3 levels.
  • LVRR was defined by echocardiographic improvements in ejection fraction and left ventricular end-diastolic diameter at 12 months.
  • Receiver operating characteristic analysis identified an optimal galectin-3 cutoff of 59 ng/ml.

Main Results:

  • 66% of patients achieved LVRR within 12 months.
  • Univariate analysis showed NYHA functional class and baseline galectin-3 levels were associated with LVRR.
  • Galectin-3 remained an independent predictor of LVRR after covariate adjustment.

Conclusions:

  • Baseline galectin-3 is an independent predictor of LVRR in RODCM.
  • Low galectin-3 levels serve as a useful biomarker for favorable ventricular remodeling in this patient group.
Abstract

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