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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in

Laura M Beaver1,2, Christiane V Lӧhr2,3, John D Clarke1,2

  • 1School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR.

Current Developments in Nutrition
|July 19, 2018
PubMed
Summary
This summary is machine-generated.

Broccoli sprouts may prevent prostate cancer by reducing cancer incidence and progression. This diet impacts epigenetic regulators like histone deacetylase 3 (HDAC3), offering a potential chemopreventive strategy.

Keywords:
TRAMP mouse modelbroccolichemopreventionepigeneticshistone H3 lysine 18 acetylation (H3K18ac)histone deacetylase (HDAC)prostate cancersulforaphane

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Area of Science:

  • Oncology
  • Epigenetics
  • Nutritional Science

Background:

  • Cruciferous vegetables show chemopreventive potential against cancer.
  • Epigenetic regulators are key targets for prostate cancer prevention.
  • Sulforaphane (SFN) from broccoli inhibits histone deacetylase (HDAC) enzymes in cancer cells.

Purpose of the Study:

  • To investigate if a broccoli sprout diet suppresses prostate cancer in the TRAMP mouse model.
  • To determine if broccoli sprouts inhibit HDAC expression and alter histone modifications.
  • To assess changes in gene expression regulated by HDACs due to broccoli sprout consumption.

Main Methods:

  • Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice were fed a diet containing 15% broccoli sprouts or a control diet.
  • Tissue samples were collected from mice at 12 and 28 weeks of age for analysis.

Main Results:

  • Broccoli sprout consumption reduced prostate cancer incidence and progression.
  • A decrease in HDAC3 protein expression and specific histone modifications (H3K9 trimethylation, H3K18 acetylation) was observed in the prostate.
  • SFN metabolites were detected in various tissues, including the prostate.

Conclusions:

  • Dietary broccoli sprouts are associated with reduced prostate cancer occurrence.
  • Broccoli sprouts may exert chemopreventive effects by downregulating HDAC3 protein expression in the prostate.
  • This study supports the role of SFN and epigenetic modulation in prostate cancer prevention.