Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Evidence for Evolution

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein Networks

Protein Networks

Directing Effect of Substituents: meta-Directing Groups

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...

Network Covalent Solids

Network Covalent Solids

Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...

Quantifying Work

Quantifying Work

As a system undergoes a change, its internal energy can change, and energy can be transferred from the system to the surroundings, or from the surroundings to the system.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluating data extraction error by a large language model from randomised controlled trials: a large-scale empirical study.

BMJ evidence-based medicine·2026

Same author

A novel visualization approach for network meta-analysis: The plate plot and the nmaplateplot R package.

Research synthesis methods·2026

Same author

Investigating the impact of problematic evidence on clinical practice guidelines and associated patient outcomes (VITALITY Study II): protocol.

BMJ open·2026

Same author

Evidence contamination: what it is and why it matters.

BMJ evidence-based medicine·2026

Same author

Tipping point analysis in network meta-analysis.

Research synthesis methods·2026

Same author

Evaluating the proper use of weighted mean difference in evidence synthesis: a meta-epidemiology study.

JBI evidence synthesis·2026

Search research articles

Related Experiment Video

Updated: Feb 7, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

Quantifying and presenting overall evidence in network meta-analysis.

¹Department of Statistics, Florida State University, Tallahassee, Florida.

Statistics in Medicine

|July 19, 2018

Summary

This summary is machine-generated.

Network meta-analysis (NMA) offers a comprehensive view of treatment comparisons. New measures quantify overall evidence, aiding audience evaluation of NMA benefits beyond direct evidence.

Keywords:

direct and indirect evidence effective number of studies effective precision effective sample size network meta-analysis

More Related Videos

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

Related Experiment Videos

Last Updated: Feb 7, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

Area of Science:

Clinical Epidemiology
Biostatistics

Background:

Network meta-analysis (NMA) synthesizes direct and indirect evidence for multi-treatment comparisons.
Existing NMA studies often lack clear reporting of comparison structures and overall evidence.
Current practice predominantly displays direct evidence, not the full benefit of NMA.

Purpose of the Study:

To classify treatment networks based on different evidence representation assumptions.
To introduce novel metrics for quantifying overall evidence in NMAs.
To enable intuitive evaluation of NMA benefits compared to pairwise meta-analyses.

Main Methods:

Classified treatment networks into three types based on edge width proportionality (number of studies, sample size, precision).
Proposed three new measures: effective number of studies, effective sample size, and effective precision.
Demonstrated derivations and interpretations using four case studies, including an illustrative example.

Main Results:

Treatment network visualizations vary significantly depending on the chosen evidence measure.
The proposed measures quantify overall evidence, including gains from indirect evidence.
Some treatment comparisons show minimal benefit from incorporating indirect evidence via NMA.

Conclusions:

Researchers should present overall evidence in NMAs for better audience comprehension.
The proposed measures facilitate preliminary evaluation of NMA quality and evidence strength.
Clear visualization of overall evidence enhances the perceived value and trustworthiness of NMAs.