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Published on: October 4, 2017
Direct Dehydrative Glycosylation of C1-Alcohols
Sloane O'Neill1, Jacob Rodriguez1, Maciej A Walczak1
1Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309, USA.
Abstract:
Due to the central role played by carbohydrates in a multitude of biological processes, there has been a sustained interest in developing effective glycosylation methods to enable more thorough investigation of their essential functions. Among the myriad technologies available for stereoselective glycoside bond formation, dehydrative glycosylation possesses a distinct advantage given the unique properties of C1-alcohols such as straightforward preparation, stability, and a general reactivity compatible with a diverse set of reaction conditions. In this Focus Review, a survey of direct dehydrative glycosylations of C1-alcohols is provided with an emphasis on recent achievements, pervading limitations, mechanistic insights, and applications in total synthesis.
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