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Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the
Mariana Séfora Bezerra Sousa1, Iasmym Melissa Soares de Holanda2, Heloísa Mirelle Costa Monteiro1
1Fellow PhD degree, Postgraduate Program in Nutrition, Department of Nutrition, Center for Health Sciences, Universidade Federal de Pernambuco (UFPE), Recife-PE, Brazil. Intellectual, scientific, conception and design of the study; acquisition, analysis and interpretation of data; technical procedures; statistical analysis; manuscript writing; final approval.
Purpose:
To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress.
Methods:
Adult and aged Wistar rats were supplemented with murici extract (150 mg/kg/day or 300 mg/kg/day) by gavage for fifteen days. Afterwards, the animals were submitted to a CSD electrophysiological recording and to brain oxidative stress evaluation.
Results:
Our results showed that aging decreased CSD propagation velocity, catalase activity and glutathione/oxidized glutathione ratio (GSH/GSSG) in the brain cortex of the rats, and increased malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) activity. The highest dose (300 mg/kg/day) of murici extract accelerated CSD, whereas the lowest (150mg/kg/day) decelerated, in both adult and aged animals. In contrast, aged animals supplemented with murici extract in both doses presented low MDA levels and high GSG/GSSG ratio in comparison to the control-aged animals.
Conclusion:
Murici extract supplementation seems to revert detrimental effects in aged brains and could be considered as a strategy in the treatment of pathologies related to aging and cortical spreading depression.
Insights
Murici extract impacts brain function, potentially reversing age-related oxidative stress and altering cortical spreading depression (CSD) in rats. This suggests a therapeutic role for murici in aging and neurological conditions.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Aging is associated with increased oxidative stress and altered brain excitability.
- Cortical spreading depression (CSD) is a key phenomenon in neurological disorders.
- Murici (Byrsonima verbascifolia) is a fruit with potential antioxidant properties.
Purpose of the Study:
- To evaluate the effects of Murici extract on CSD.
- To assess the impact of Murici extract on brain oxidative stress markers.
- To investigate these effects in both adult and aged Wistar rats.
Main Methods:
- Rats received Murici extract (150 or 300 mg/kg/day) orally for 15 days.
- Electrophysiological recordings were used to measure CSD propagation velocity.
- Brain oxidative stress was evaluated by measuring MDA, GSH/GSSG ratio, SOD, and catalase activity.
Main Results:
- Aging reduced CSD velocity and antioxidant capacity (catalase, GSH/GSSG), while increasing oxidative damage (MDA) and SOD activity.
- Murici extract at 300 mg/kg/day accelerated CSD, while 150 mg/kg/day decelerated it in both age groups.
- Murici extract supplementation in aged rats lowered MDA and increased the GSH/GSSG ratio, indicating reduced oxidative stress.
Conclusions:
- Murici extract appears to counteract age-related detrimental effects on the brain.
- Supplementation with Murici extract may be a viable strategy for managing aging-related pathologies.
- Further research into Murici extract for conditions involving CSD and oxidative stress is warranted.
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