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Updated: Feb 7, 2026

Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein
Published on: January 13, 2026
Direct cost of maintenance of totally implanted central venous catheter patency
Rafael Fernandes Bel Homo1, Antônio Fernandes Costa Lima2
1MSc, RN, Clinical Research, Instituto do Câncer Do Estado de São Paulo, São Paulo, SP, Brazil.
Insights
Maintaining totally implanted central venous catheters with heparin costs an average of $9.71. Replacing heparin with 0.9% sodium chloride reduces this cost by $0.90 per procedure, aiding cost containment.
Area of Science:
- Oncology Nursing
- Healthcare Economics
- Vascular Access Devices
Background:
- Totally implanted central venous catheters (TICVCs) are crucial for cancer patient treatment.
- Maintaining catheter patency is essential but incurs direct costs.
- Heparin is commonly used for TICVC maintenance, but its cost-effectiveness warrants investigation.
Purpose of the Study:
- To determine the average direct cost of maintaining TICVC patency with heparin.
- To estimate the cost savings associated with replacing heparin with 0.9% sodium chloride for TICVC maintenance.
Main Methods:
- A quantitative, exploratory-descriptive study was conducted.
- 200 non-participant observations of TICVC maintenance procedures were performed.
- Direct costs were calculated based on professional time, workforce costs, and material expenses.
Main Results:
- The average direct cost for heparin maintenance was $9.71 (SD=$1.35).
- The average direct cost for 0.9% sodium chloride maintenance was $8.81 (SD=$1.29).
- Using sodium chloride resulted in an average cost reduction of $0.90 per procedure.
Conclusions:
- Replacing heparin with 0.9% sodium chloride is a viable strategy for reducing TICVC maintenance costs.
- These findings support cost containment initiatives in cancer patient care.
- Optimizing TICVC maintenance protocols can improve resource allocation in healthcare settings.
Objective:
to identify the average direct cost of maintaining the patency of totally implanted central venous catheter with heparin at a Day Hospital of a public hospital of high complexity specialized in the treatment of cancer patients, and estimate the average direct cost of replacing heparin with sodium chloride 0.9%.
Method:
quantitative, exploratory-descriptive study, with a sample of 200 non-participant observations of the maintenance of totally implanted central venous catheters with heparin. The average direct cost was calculated by multiplying the (clocked) time spent by professionals to complete the procedure by the direct unit cost of workforce, added to the cost of materials and solutions.
Results:
the estimated total direct cost of catheter maintenance with heparin was US$ 9.71 (SD=1.35) on average, ranging from US$ 7.98 to US$ 23.28. The estimated total direct cost of maintenance with 0.9% sodium chloride in the place of heparin was US$ 8.81 (SD=1.29) on average, resulting in a reduction of US$ 0.90 per procedure.
Conclusion:
the results contributed to propose strategies to assist in cost containment/minimization in this procedure. The replacement of heparin by 0.9% sodium chloride proved to be an option to reduce the total average direct cost.
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