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Development of a Larval Zebrafish Infection Model for Clostridioides difficile
Published on: February 14, 2020
Repurposing an Old Drug for a New Epidemic: Ursodeoxycholic Acid to Prevent Recurrent Clostridioides difficile
Brandon J Webb1,2, Ali Brunner3, Julia Lewis4
1Intermountain Healthcare, Division of Epidemiology and Infectious Diseases, Salt Lake City, Utah.
Abstract:
Recurrent Clostridioides difficile infection (rCDI) may be mediated in part by secondary bile acids. Here we report salvage therapy with ursodeoxycholic acid (UDCA) to prevent rCDI in 16 high-risk patients. Patients on UDCA had a low observed recurrence rate (12.5%). Controlled trials are needed to confirm these observations.
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