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Published on: April 25, 2012
Pharmacology and Therapeutic Potential of the 5-HT7 Receptor
Kevin M Blattner1, Daniel J Canney1, Douglas A Pippin2
1Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery Research , 3307 North Broad Street , Philadelphia , Pennsylvania 19140 , United States.
Abstract:
It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first identified in 1993. Over the course of the last 25 years, this receptor has been the subject of intense investigation, and it has been demonstrated that 5-HT7 plays an important role in a wide range of pharmacological processes. As a result of these findings, modulation of 5-HT7 activity has been the focus of numerous drug discovery and development programs. This review provides an overview of the roles of 5-HT7 in normal physiology and the therapeutic potential of this interesting drug target.
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