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Related Experiment Video

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Viral Nanoparticles for In vivo Tumor Imaging
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Case 260.

Ryan G Short1, Tina D Tailor1

  • 1From the Department of Radiology, Duke University Medical Center, DUMC Box 3808, Durham, NC 27710.

Radiology
|July 19, 2018
PubMed
Summary
This summary is machine-generated.

A lung transplant recipient with cystic fibrosis developed a new cough and obstructive lung disease. Imaging revealed a suspicious mass, prompting further investigation for potential complications post-transplant.

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Area of Science:

  • Pulmonary Medicine
  • Transplant Surgery
  • Radiology

Background:

  • Cystic fibrosis (CF) lung transplant recipients face risks of infection and rejection.
  • New onset of respiratory symptoms like cough can indicate serious complications.

Purpose of the Study:

  • To investigate the cause of new-onset cough and obstructive lung disease in a bilateral orthotopic lung transplant recipient with a history of CF.

Main Methods:

  • Clinical evaluation, pulmonary function testing, sputum cultures, chest radiography, CT scan, and PET/CT imaging were utilized.
  • Patient was on a standard immunosuppression regimen including mycophenolate mofetil, prednisone, and tacrolimus.

Main Results:

  • The patient presented with a new cough and decreased FEV1/FVC ratio, indicating an obstructive lung process.
  • Sputum cultures previously grew Pseudomonas and MRSA, but no active infection was found on bronchoscopy.
  • Imaging studies (chest CT and PET/CT) were performed to evaluate the cause of symptoms.

Conclusions:

  • Further investigation is warranted to determine the etiology of the obstructive lung process and mass in this lung transplant recipient.
  • The findings highlight the importance of vigilant monitoring for complications in post-lung transplant patients.