Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

Cell Specific Gene Expression

Cell Specific Gene Expression

Synaptic Signaling

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.

Synaptic Signaling

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...

Cognitive Dissonance

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...

Phase-lead and Phase-lag Controllers

Phase-lead and Phase-lag Controllers

Understanding the working function of different types of controllers can be illustrated with practical analogies, such as adjusting a stereo's volume equalizer. Cranking up the bass involves a phase-lead controller, which functions as a high-pass filter, while increasing the treble uses a phase-lag controller, which acts as a low-pass filter. PD controllers, similar to high-pass filters, enhance the system's response to high-frequency components. PI controllers, akin to low-pass...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Trends in colorectal cancer mortality in China from 2004 to 2021: an epidemiological analysis based on national disease surveillance data.

Frontiers in oncology·2026

Same author

Effects of pesticides on soil microbial community structure and nitrogen transformation in tobacco fields affected by root rot.

Frontiers in microbiology·2026

Same author

Microglia in Post-Traumatic Brain Injury (TBI) Cognitive Impairment: From Pathological Changes to Therapeutic Approaches.

CNS neuroscience & therapeutics·2025

Same author

Menin Reduces Parvalbumin Expression and is Required for the Anti-Depressant Function of Ketamine.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023

Same author

Daprodustat and On-Treatment Cardiovascular Events in Chronic Kidney Disease.

The New England journal of medicine·2022

Same author

Protective effect of leukemia inhibitory factor on the retinal injury induced by acute ocular hypertension in rats.

Experimental and therapeutic medicine·2022

Search research articles

Related Experiment Video

Updated: Feb 7, 2026

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression.

Kai Zhuang¹, Changquan Huang¹, Lige Leng¹

¹Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China.

|July 19, 2018

Summary

Menin protein (MEN1) is vital for brain function. Deleting it in neurons impairs learning and memory by affecting synaptic connections through the p35-Cdk5 pathway.

Keywords:

Cdk5 cognition menin p35 synaptic function

More Related Videos

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

Related Experiment Videos

Last Updated: Feb 7, 2026

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Menin (MEN1) is crucial for tissue development and linked to MEN1 syndrome.
Menin is abundant in the nervous system, but its adult brain function is unclear.

Purpose of the Study:

To investigate the role of menin in the adult brain, specifically its impact on neuronal structure and cognitive functions.
To elucidate the molecular mechanisms by which menin influences synaptic function and learning.

Main Methods:

Generated neuron-specific Men1 conditional knockout (CcKO) mice.
Assessed dendritic branching, spine formation, synaptic function, learning, and memory in CcKO mice.
Investigated menin's interaction with the p35 promoter and its effect on p35 transcription.

Main Results:

Neuron-specific deletion of Men1 (CcKO) led to defects in dendritic branching and spine formation.
CcKO mice exhibited impaired synaptic function, learning, and memory.
Menin was found to bind the p35 promoter, enhancing p35 transcription.
Restoring p35 expression in CcKO mice rescued synaptic and cognitive deficits.

Conclusions:

Menin plays a critical role in maintaining synaptic and cognitive function in the adult brain.
Menin modulates the p35-Cdk5 pathway, which is essential for synaptic plasticity and cognitive processes.
Targeting the menin-p35-Cdk5 pathway may offer therapeutic strategies for cognitive impairments.