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Large-Volume Infusions into the Brain: A Comparative Study of Catheter Designs

Martin L Brady1, Raghu Raghavan1, Jaime Mata2

  • 1Therataxis LLC, Baltimore, Maryland, USA.

Stereotactic and Functional Neurosurgery
|July 19, 2018
PubMed
Abstract

Insights

A novel porous brain infusion catheter (PBIC) shows promise for uniform drug delivery in large brain volumes. This new catheter may improve treatments for neurodegenerative diseases and brain cancers.

Area of Science:

  • Neurosurgery
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Whole-brain infusions are crucial for treating neurodegenerative diseases and brain cancers.
  • Current single-port catheters may not adequately deliver drugs to large brain volumes.
  • Uniform drug distribution is essential for effective disease-modifying therapies.

Purpose of the Study:

  • To evaluate a novel porous brain infusion catheter (PBIC) for large-volume infusions.
  • To compare the PBIC's distribution performance against a conventional step-end port catheter (SEPC).
  • To assess the potential of the PBIC for therapeutic applications in human clinical trials.

Main Methods:

  • A porous brain infusion catheter (PBIC) was designed and tested.
  • In vivo studies were conducted in porcine brains (n=8).
  • The PBIC was compared with a step-end port catheter (SEPC) using identical catheter tip placements.

Main Results:

  • Both the PBIC and SEPC demonstrated comparable performance.
  • The PBIC showed a statistically significant advantage in achieving larger drug distributions (p ≈ 0.045).
  • Five infusions were performed with each catheter type.

Conclusions:

  • The PBIC demonstrates effective large-volume infusion capabilities.
  • The device is suitable for further investigation in human clinical trials.
  • The PBIC offers a promising solution for uniform drug delivery in the brain.
Keywords:
Convection-enhanced deliveryIn vivo infusionsMicro-RNAParkinson’s diseasePorcine modelPorous brain infusion catheterSmall interfering RNA

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