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Parainfluenza virus bronchiolitis. Epidemiology and pathogenesis
American Journal of Diseases of Children (1960)
|January 1, 1986
Summary
Parainfluenza virus (PV) causes bronchiolitis, particularly in non-Caucasian males. Breastfeeding reduces risk, while smoke exposure and bottle feeding increase recurrent wheezing in infants with PV bronchiolitis.
Area of Science:
- Pediatrics
- Virology
- Immunology
Background:
- Bronchiolitis is a common respiratory infection in infants.
- Parainfluenza virus (PV) is a significant causative agent of bronchiolitis.
- Understanding PV bronchiolitis epidemiology and pathogenesis is crucial for prevention and treatment.
Purpose of the Study:
- To investigate the epidemiology and pathogenesis of bronchiolitis caused by parainfluenza virus (PV).
- To identify risk factors and immune responses associated with PV bronchiolitis and recurrent wheezing.
Main Methods:
- Epidemiological analysis of patient demographics and feeding methods.
- Assessment of immune responses, including cell-mediated immunity and IgE titers.
- Comparison of patients with bronchiolitis versus upper respiratory tract infection.
Main Results:
- PV bronchiolitis was more common in non-Caucasian males.
- Breastfeeding was associated with a reduced risk of bronchiolitis.
- Cigarette smoke exposure and bottle feeding increased recurrent wheezing after PV bronchiolitis.
- Subsequent viral infections uniformly resulted in wheezing.
- Higher cell-mediated immune responses and PV-specific IgE titers were observed in bronchiolitis patients.
Conclusions:
- PV bronchiolitis shares epidemiological and pathogenic similarities with respiratory syncytial virus (RSV) bronchiolitis.
- Lower respiratory tract infections may predispose infants to bronchoconstriction.
- Environmental factors like smoke exposure and feeding methods influence disease outcomes and recurrence.