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Updated: Feb 7, 2026
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
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Biomolecular Consequences of Platelet Pathogen Inactivation Methods
Hendrik B Feys1, Britt Van Aelst2, Veerle Compernolle3
1Transfusion Research Center, Belgian Red Cross-Flanders, Ghent, Belgium; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Transfusion Medicine Reviews
|July 20, 2018
Summary
Pathogen inactivation (PI) methods for platelet concentrates (PC) enhance blood safety by inactivating viruses and bacteria. However, these photochemical treatments may impact platelet function and hemostasis, requiring further study.
Area of Science:
- Transfusion Medicine
- Hematology
- Biochemistry
Background:
- Pathogen inactivation (PI) is crucial for reducing infectious disease transmission via blood products.
- Platelet concentrates (PC) are treated with PI methods to inactivate viruses, bacteria, and parasites.
- Current PI methods primarily target pathogen nucleic acids using photochemical damage.
Purpose of the Study:
- To review the biomolecular effects of PI treatment on platelets.
- To understand the impact of PI on platelet function and hemostasis.
- To compare the distinct effects of different PI methods on platelets.
Main Methods:
- Literature review of studies on pathogen inactivation in transfusion medicine.
- Analysis of photochemical mechanisms and their impact on platelet biomolecules.
- Synthesis of current research on the effects of PI on platelet function.
Main Results:
- Photochemical PI methods, while effective against pathogens, can alter platelet biomolecules.
- The impact of these biomolecular changes on platelet function and hemostasis is not fully understood.
- Different PI methods exhibit varying effects on platelet biochemistry and function.
Conclusions:
- Pathogen inactivation treatments affect platelets differently, despite a common photochemical principle.
- Understanding these biomolecular effects is essential for clinical use and implementation of PI platelets.
- Further research is needed to elucidate the full impact of PI on platelet efficacy and patient outcomes.
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