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Recanalization in Cerebral Venous Thrombosis
Diana Aguiar de Sousa1,2,3, Lia Lucas Neto4,3, Patrícia Canhão1,2,5
1From the Department of Neurosciences and Mental Health (D.A.d.S., P.C., J.M.F.).
Stroke
|July 20, 2018
Summary
Recanalization in cerebral venous thrombosis (CVT) occurs in 85% of patients treated with anticoagulation. Achieving recanalization significantly improves clinical outcomes, while lack of it is linked to worse results.
Area of Science:
- Neurology
- Vascular Medicine
- Medical Imaging
Background:
- Cerebral venous thrombosis (CVT) is a rare but serious condition.
- The impact of venous recanalization on patient outcomes in CVT remains unclear.
Purpose of the Study:
- To systematically review the recanalization rate in CVT patients.
- To assess the association between recanalization and clinical outcomes.
- To investigate the relationship between recanalization and CVT recurrence.
Main Methods:
- Systematic literature search of MEDLINE, Cochrane Library, and clinicaltrials.gov.
- Inclusion of cohort studies on adult CVT patients treated with anticoagulation.
- Meta-analysis of recanalization rates, functional outcomes (modified Rankin Scale), and CVT recurrence.
Main Results:
- Overall pooled recanalization rate was 85% (95% CI, 80-89%) in 818 CVT cases.
- Higher quality studies reported a 77% recanalization rate (95% CI, 70-82%).
- Recanalization was associated with a significantly higher chance of favorable outcome (OR, 3.3; 95% CI, 1.2-8.9).
Conclusions:
- Anticoagulation therapy leads to an 85% recanalization rate in CVT patients.
- Lack of venous recanalization is associated with poorer clinical outcomes.
- Potential bias exists due to the exclusion of severely ill patients from follow-up imaging.
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