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Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
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Published on: October 24, 2019

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Renoprotective effects of a factor Xa inhibitor: fusion of basic research and a database analysis

Yuya Horinouchi1, Yasumasa Ikeda2, Keijo Fukushima3

  • 1Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan. horinouchi@tokushima-u.ac.jp.

Scientific Reports
|July 20, 2018
PubMed

Insights

Activated Factor Xa (FXa) contributes to kidney disease. FXa inhibitors like edoxaban show protective effects against renal tubulointerstitial fibrosis and may reduce chronic kidney disease progression.

Area of Science:

  • Nephrology
  • Hematology
  • Pharmacology

Background:

  • Renal tubulointerstitial injury is a key driver of chronic kidney disease (CKD).
  • Elevated levels of activated Factor Xa (FXa), a coagulation factor, are observed in inflammatory conditions.
  • The role of FXa in renal tubulointerstitial injury and fibrosis requires further investigation.

Purpose of the Study:

  • To investigate the renoprotective effects of an FXa inhibitor against renal tubulointerstitial injury.
  • To explore the potential of FXa inhibition in mitigating chronic kidney disease (CKD) progression.

Main Methods:

  • Utilized a unilateral ureteral obstruction (UUO) mouse model to induce renal tubulointerstitial fibrosis.
  • Administered the FXa inhibitor edoxaban to UUO mice and assessed renal pathology.
  • Analyzed the Food and Drug Administration Adverse Events Reporting System (FAERS) database for tubulointerstitial nephritis reports.

Main Results:

  • Renal expression of Factor X (FX) and its receptors (PAR-1, PAR-2) were elevated in UUO mice.
  • Edoxaban treatment significantly suppressed UUO-induced tubulointerstitial fibrosis and extracellular matrix deposition.
  • Edoxaban attenuated macrophage infiltration and inflammatory molecule upregulation in UUO kidneys.
  • FAERS database analysis revealed fewer tubulointerstitial nephritis reports in patients on FXa inhibitors.

Conclusions:

  • FXa plays a significant role in promoting renal tubulointerstitial fibrosis.
  • FXa inhibitors, such as edoxaban, demonstrate renoprotective effects by inhibiting fibrosis.
  • Targeting FXa may represent a novel therapeutic strategy for managing chronic kidney disease (CKD).

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