Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Septins01:02

Role of Septins

2.2K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
The Role of Culture01:23

The Role of Culture

433
Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
433
Role-Based Identity01:21

Role-Based Identity

214
Role-based identities are central to understanding how individuals navigate social environments by adopting distinct self-conceptions aligned with various societal roles. These identities are not fixed traits but are constructed through personal actions and the social feedback individuals receive in context-specific interactions. Each social role, such as student, teacher, or friend, carries a set of expectations and norms that influence how people think, feel, and behave within that...
214
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.6K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.6K
Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

7.2K
Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
7.2K
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

1.2K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The calcium-sensing receptor has only a parathyroid hormone-dependent role in the acute response of renal phosphate transporters to phosphate intake.

American journal of physiology. Renal physiology·2024
Same author

Acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals.

Acta physiologica (Oxford, England)·2022
Same author

1,25(OH)<sub>2</sub> vitamin D<sub>3</sub> stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine.

The Journal of physiology·2020
Same author

Intestinal epithelial ablation of Pit-2/Slc20a2 in mice leads to sustained elevation of vitamin D<sub>3</sub> upon dietary restriction of phosphate.

Acta physiologica (Oxford, England)·2020

Related Experiment Video

Updated: Feb 7, 2026

Identification of Protein Interacting Partners Using Tandem Affinity Purification
10:02

Identification of Protein Interacting Partners Using Tandem Affinity Purification

Published on: February 25, 2012

38.3K

NaPi-IIa interacting partners and their (un)known functional roles.

Nati Hernando1

  • 1Institute of Physiology, University Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. hernando@physiol.uzh.ch.

Pflugers Archiv : European Journal of Physiology
|July 20, 2018
PubMed
Summary
This summary is machine-generated.

Identifying protein partners for the Na+/phosphate cotransporter NaPi-IIa is crucial for understanding its regulation. This review details identified partners and their effects on NaPi-IIa expression and function.

Keywords:
Interacting proteinsNaPi-IIaPhosphateRenal proximal tubuleSlc34a1

More Related Videos

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

13.0K
Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics
12:53

Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics

Published on: July 6, 2014

32.0K

Related Experiment Videos

Last Updated: Feb 7, 2026

Identification of Protein Interacting Partners Using Tandem Affinity Purification
10:02

Identification of Protein Interacting Partners Using Tandem Affinity Purification

Published on: February 25, 2012

38.3K
Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

13.0K
Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics
12:53

Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics

Published on: July 6, 2014

32.0K

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Protein-protein interactions mediate protein localization and regulatory processes.
  • Identifying functional roles of interacting partners remains challenging.
  • The Na+/phosphate cotransporter NaPi-IIa plays a vital role in phosphate homeostasis.

Purpose of the Study:

  • To review the identification of NaPi-IIa interacting partners.
  • To elucidate the functional impact of these interactions on NaPi-IIa.

Main Methods:

  • Literature review of studies identifying NaPi-IIa partners.
  • Analysis of experimental data on the effects of these interactions.

Main Results:

  • Several protein partners of NaPi-IIa have been identified.
  • These interactions influence NaPi-IIa expression and/or regulation.

Conclusions:

  • Understanding NaPi-IIa interacting partners is key to its functional regulation.
  • Further research into these interactions will advance knowledge of phosphate transport.