Related Experiment Video
Updated: Feb 7, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
Published on: May 19, 2023
Peritoneal perforation during transanal endoscopic microsurgery is not associated with significant short-term
Jonathan Ramkumar1, Ahmer A Karimuddin1,2, P Terry Phang1,2
1Division of General Surgery, University of British Columbia, Vancouver, Canada.
Background:
In patients treated by transanal endoscopic microsurgery (TEM), breach of the peritoneal cavity is a feared intraoperative challenge. Our aim is to analyze predictors and short-term outcomes of patients with peritoneal perforation (TEM-P) when compared to similar patients with no peritoneal compromise (TEM-N).
Methods:
At St. Paul's Hospital, demographic, surgical, pathologic, and follow-up data for all patients treated by TEM is maintained in a prospectively populated database. A retrospective review was performed and two groups were established for comparison: TEM-P and TEM-N. Statistical analysis was performed using student's t or chi-squared test, where appropriate.
Results:
Of 619 patients treated by TEM between 2007 and 2016, 39 (6%) patients were in the TEM-P group and 580 (94%) in the TEM-N group. There were no differences between the groups in patient age, gender, histology, or tumor size. Patients who had peritoneal perforations had more proximal lesions (11 vs. 7 cm, p < 0.0001), anterior lesions (56 vs. 43%, p < 0.05), and longer operations (80 vs. 51 min, p < 0.005). While most defects were closed endoluminally, 2 patients with perforation were converted to transabdominal surgery. There was a difference in overall hospital stay with TEM-P patients staying on average 2 days in hospital with fewer patients managed as day surgery (31 vs. 73%, p < 0.0001). There were no mortalities or significant 30-day complications in the TEM-P group and only one patient required readmission.
Conclusions:
The St. Paul's Hospital TEM experience suggests patients with peritoneal breach during TEM can be safely managed with outcomes similar to patients without peritoneal entry. Proximal, anterior lesions are at highest risk of peritoneal perforation.
Insights
Transanal endoscopic microsurgery (TEM) peritoneal perforation occurs in 6% of patients. Proximal, anterior lesions increase risk, but outcomes are similar to patients without perforation, with safe management possible.
Area of Science:
- Colorectal Surgery
- Minimally Invasive Surgery
- Surgical Outcomes
Background:
- Transanal endoscopic microsurgery (TEM) is a surgical technique for rectal lesions.
- Peritoneal cavity breach (TEM-P) is a known intraoperative complication.
- Understanding predictors and outcomes of TEM-P is crucial for patient safety.
Purpose of the Study:
- To analyze predictors of peritoneal perforation during TEM.
- To compare short-term outcomes of patients with TEM-P versus those without (TEM-N).
- To identify patient and tumor characteristics associated with peritoneal breach.
Main Methods:
- Retrospective review of a prospectively maintained database of TEM patients (2007-2016).
- Comparison of two groups: TEM-P (peritoneal perforation) and TEM-N (no peritoneal compromise).
- Statistical analysis using t-tests and chi-squared tests.
Main Results:
- 39 patients (6%) experienced TEM-P out of 619 total TEM procedures.
- TEM-P was associated with more proximal (11 vs. 7 cm) and anterior (56% vs. 43%) lesions.
- TEM-P patients had longer operations (80 vs. 51 min) and hospital stays (2 days), with fewer day surgeries (31% vs. 73%).
Conclusions:
- Peritoneal breach during TEM can be safely managed with outcomes comparable to patients without perforation.
- Proximal and anterior rectal lesions are identified as key predictors of peritoneal perforation during TEM.
- The study highlights the feasibility of managing TEM-P without significant short-term morbidity.
Related Concept Videos
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Hemodialysis II: Procedure and Complications
Long-term Depression
Pneumonia III: Complications and Assessment
Diabetes: Symptoms, Diagnosis, and Complications

