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[Neurosecretory synapses, yesterday and today]
Annales D'Endocrinologie
|January 1, 1985
Summary
J. Barry first described peptidergic neurotransmission in the mammalian brain in 1954-55. His discovery was initially overlooked due to restrictive definitions in neuroendocrinology, highlighting the concept of premature scientific discovery.
Area of Science:
- Neurobiology
- Neuroendocrinology
Context:
- The study examines the historical context of peptidergic neurotransmission in the central nervous system.
- It highlights J. Barry's 1954-55 observations of "Gomori-positive" synapses in the mammalian brain using light microscopy.
Purpose:
- To explore the initial formulation and subsequent reception of Barry's findings on peptidergic neurotransmission.
- To analyze the epistemological reasons behind the delayed recognition of this discovery.
Summary:
- Barry's observations of "Gomori-positive" synapses were foundational to understanding peptidergic neurotransmission.
- The neuroendocrinology field's restrictive definition of "neurosecretion" impeded the acceptance of Barry's findings for approximately twenty years.
Impact:
- This case serves as an example of a "premature discovery" in science.
- It raises epistemological questions about scientific acceptance and the evolution of neurobiology and neuroendocrinology.