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Updated: Feb 7, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
09:58

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Published on: December 9, 2016

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang1, Rene Bernards2

  • 1Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Frontiers of Medicine
|July 20, 2018
PubMed

Insights

Drug resistance in cancer can be overcome by sequential therapies. This approach exploits cancer cells' acquired vulnerabilities, offering a promising new strategy for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Molecularly targeted cancer drugs have emerged due to identified driver mutations.
  • Drug resistance remains a significant limitation, mirroring challenges seen with conventional chemotherapy.
  • Existing combination therapies aim to prevent resistance, but this study explores exploiting resistance itself.

Purpose of the Study:

  • To explore therapeutic strategies that leverage cancer cell changes resulting from drug resistance.
  • To investigate the concept of collateral sensitivity for novel cancer treatment approaches.
  • To present sequential drug therapies as a viable clinical strategy.

Main Methods:

  • Reviewing therapeutic approaches that exploit the fitness cost associated with cancer drug resistance.
  • Discussing the development and application of sequential drug therapies.
  • Highlighting the concept of inducing drug sensitivity through initial non-curative treatments.

Main Results:

  • Drug resistance can impose a fitness cost on cancer cells, creating exploitable vulnerabilities.
  • Sequential drug administration, where the first drug induces sensitivity to the second, is a promising strategy.
  • The concept of collateral sensitivity offers a novel therapeutic avenue.

Conclusions:

  • Exploiting drug-induced vulnerabilities in cancer cells presents a promising therapeutic strategy.
  • Sequential drug therapies, utilizing collateral sensitivity, hold significant potential for clinical application in cancer treatment.
  • This approach offers a new paradigm beyond conventional combination therapies for overcoming drug resistance.
Keywords:
cancerdrug resistancegenetic screenssenescencetargeted therapy

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