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Impact of donor coronary angiography on kidney transplantation outcomes

Mathieu Lesouhaitier1, Camille Legeai2, Emilie Savoye2

  • 1Division of Nephrology, CHU Rennes, Rennes, France.

Clinical Transplantation
|July 20, 2018
PubMed

Insights

Coronary angiography (CA) in organ donors does not increase the risk of delayed graft function (DGF) in kidney transplant recipients. This evaluation is safe and does not negatively impact kidney graft outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Transplantation

Background:

  • Coronary angiography (CA) is essential for evaluating potential multi-organ donors.
  • Iodinated contrast media used in CA may pose a risk of contrast-induced acute kidney injury (CI-AKI) and delayed graft function (DGF).

Purpose of the Study:

  • To investigate the impact of CA on kidney graft outcomes in recipients from donors aged 45-70 years with cardiovascular risk factors.
  • To determine if CA influences the incidence and severity of DGF and long-term graft function.

Main Methods:

  • Retrospective analysis of kidney transplant data from the CRISTAL database (March 2012 - June 2014).
  • Inclusion criteria: recipients of kidneys from donors aged 45-70 without cardiac contraindications but with cardiovascular risk factors.
  • Exclusion criteria: preemptive transplant, multi-organ transplant, recipient death within 8 days post-transplant.

Main Results:

  • DGF occurred in 38.9% of recipients from donors with CA versus 45.5% from donors without CA.
  • Multivariate analysis indicated that CA or repeated contrast injections did not significantly influence the risk of DGF.
  • CA did not increase the risk of primary non-function, DGF duration, hospital stay, or affect 1-year graft function.

Conclusions:

  • Coronary angiography in potential kidney donors does not adversely affect kidney graft outcomes, including delayed graft function and long-term function.
  • The use of iodinated contrast media during CA for donor evaluation is safe regarding kidney transplant success.

Keywords:
coronary angiographydelayed graft functionkidney transplantation

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