Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension I: Introduction01:28

Hypertension I: Introduction

921
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
921
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

980
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
980
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

458
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
458
Resistivity01:22

Resistivity

4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

6.0K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
Equivalent Resistance01:16

Equivalent Resistance

991
In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
991

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood flow in the human cerebral cortex: Large-scale pial vascularization and 1D simulation.

PLoS computational biology·2025
Same author

Arterial Stiffness, Central Blood Pressure, and the Risk of Incident Stroke in Hypertensive Adults.

European journal of neurology·2025
Same author

Cost-Utility Analysis of Low-Dose Pioglitazone in a Population With Prediabetes and a History of Stroke or Transient Ischemic Attack.

Journal of the American Heart Association·2024
Same author

Letter to the Editor From Spence: [Prevalence and Characteristics of Low-Renin Hypertension in a Primary Care Population].

Journal of the Endocrine Society·2024
Same author

Vessel Wall Volume and Plaque Volume Should Replace Carotid Intima-Media Thickness.

American journal of hypertension·2024
Same author

Vertebrobasilar ischemia: Some less recognized aspects.

International journal of stroke : official journal of the International Stroke Society·2022
Same journal

RNA-binding protein interacting with circular RNAs: potential multitarget therapeutic strategies in ischaemic stroke.

Stroke and vascular neurology·2026
Same journal

ZL006-05 prevents tPA-induced haemorrhagic transformation after stroke via inhibiting neutrophil myeloperoxidase-related pathway.

Stroke and vascular neurology·2026
Same journal

Cough reflex testing for dysphagia severity and pneumonia risk after acute stroke: a prospective observational study.

Stroke and vascular neurology·2026
Same journal

Chinese stroke association guidelines on construction of direct transfer to angiography suite.

Stroke and vascular neurology·2026
Same journal

Development and validation of an explainable prediction model for post-stroke epilepsy in patients with ischaemic stroke following mechanical thrombectomy: a multicentre retrospective cohort study.

Stroke and vascular neurology·2026
Same journal

Endothelial dysfunction mediates inflammation-driven poor prognosis in symptomatic intracranial atherosclerosis stenosis.

Stroke and vascular neurology·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

752

Controlling resistant hypertension.

J David Spence1

  • 1Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada.

Stroke and Vascular Neurology
|July 20, 2018
PubMed
Summary
This summary is machine-generated.

Resistant hypertension, a major stroke risk, is poorly controlled in China. Personalized, physiologically-guided therapy, including dietary changes and specific medications, can significantly improve blood pressure control.

More Related Videos

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

795
Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis
07:11

Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis

Published on: May 23, 2025

955

Related Experiment Videos

Last Updated: Feb 7, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

752
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

795
Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis
07:11

Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis

Published on: May 23, 2025

955

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Resistant hypertension is a significant, preventable cause of stroke.
  • Hypertension prevalence is high in China, with low control rates (~6%).
  • Most strokes occur in patients with resistant hypertension, highlighting the need for better blood pressure management.

Purpose of the Study:

  • To address the challenges of resistant hypertension management in China.
  • To explore effective strategies for improving blood pressure control.
  • To emphasize the importance of individualized, physiologically-based treatment approaches.

Main Methods:

  • Reviewing factors contributing to uncontrolled hypertension, including non-compliance, lifestyle, and therapeutic/diagnostic inertia.
  • Highlighting the role of dietary interventions like sodium restriction and Mediterranean/DASH diets.
  • Discussing physiologically individualized therapy based on plasma renin activity and aldosterone levels.

Main Results:

  • Dietary modifications can lower blood pressure proportionally to hypertension severity.
  • Physiologically individualized therapy significantly improves blood pressure control.
  • Specific treatments are recommended based on renin-aldosterone profiles: angiotensin receptor antagonists for renal hypertension, aldosterone antagonists for primary aldosteronism, and amiloride for Liddle phenotype.

Conclusions:

  • Effective management of resistant hypertension is crucial for stroke prevention.
  • Dietary changes and individualized, phenotyping-based therapy are key to improving blood pressure control.
  • Underdiagnosed conditions like the Liddle phenotype require greater clinical awareness and appropriate treatment with amiloride.