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Updated: Feb 7, 2026

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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Diet for stroke prevention.

J David Spence1,2

  • 1Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada.

Stroke and Vascular Neurology
|July 20, 2018
PubMed
Summary
This summary is machine-generated.

Dietary shifts in China, including increased meat and egg consumption, correlate with rising heart disease and stroke risks. Adopting a plant-rich Mediterranean diet and reducing sodium intake may help prevent cardiovascular events.

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Area of Science:

  • Cardiovascular Science
  • Nutritional Epidemiology
  • Microbiome Research

Background:

  • Lifestyle factors, particularly diet, significantly influence cardiovascular health.
  • China has experienced a marked increase in coronary and stroke mortality in recent decades.
  • Dietary changes linked to increased prosperity include higher meat/egg intake and lower fruit/vegetable/whole grain consumption.

Purpose of the Study:

  • To investigate the link between dietary changes, gut microbiome metabolites, and cardiovascular risk in China.
  • To evaluate the role of trimethylamine N-oxide (TMAO) in atherosclerosis development.
  • To identify dietary strategies for preventing stroke and myocardial infarction.

Main Methods:

  • Analysis of dietary patterns and their correlation with mortality trends.
  • Investigation of the microbial conversion of dietary components (carnitine, phosphatidylcholine) to TMAO.
  • Review of evidence supporting the Mediterranean diet for cardiovascular prevention.

Main Results:

  • Increased meat and egg intake in China is associated with rising coronary and stroke mortality.
  • Dietary carnitine and phosphatidylcholine are converted by the gut microbiome to TMAO.
  • High TMAO levels are linked to increased cardiovascular risk and atherosclerosis.

Conclusions:

  • Dietary modifications are crucial for preventing the rise in cardiovascular disease in China.
  • Reducing red meat and egg yolk intake, while increasing fruits, vegetables, and whole grains, is recommended.
  • Adopting a Mediterranean-style diet and reducing sodium intake are key strategies for stroke prevention.