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The negative cooperativity in cytochrome c oxidase redox reactions: the electrostatic effect
Archives of Biochemistry and Biophysics
|December 1, 1985
Abstract:
The electrostatic interaction of two hemes is calculated on the basis of the data on the cytochrome c oxidase structure. The interaction energy corresponds to the positive shift by approximately greater than 100 mV of the redox potential of one of the hemes when the other is oxidized. This effect seems to be the most likely reason of the negative cooperativity in the redox behavior of cytochrome c oxidase.