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Published on: January 26, 2024
Gastroparesis in a Patient with Gastric AL Amyloidosis
Matthew Hoscheit1, Afrin Kamal2, Michael Cline2
1Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Abstract:
Systemic amyloidosis is a group of complex disorders characterized by the extracellular deposition of nonbranching fibrils in various tissues, ultimately leading to a variety of clinical presentations including isolated or multiorgan dysfunction. Amyloid involvement of the gastrointestinal tract is common depending on the subtype of this disease; light chain primary amyloidosis (AL) and secondary amyloidosis (AA) affect the gastrointestinal tract in unique ways due to differing pathophysiology. A case is reported of gastroparesis associated with AL amyloidosis diagnosed by esophagogastroduodenoscopy and study of gastric emptying, then subsequently confirmed by Congo red staining performed on endoscopic biopsies.
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