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Anti-Quorum Sensing Natural Compounds
1Department of Medical Microbiology and Parasitology, Faculty of Medicine, Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Journal of Microscopy and Ultrastructure
|July 20, 2018
Summary
Drug resistance necessitates new anti-virulence drugs. This review explores medicinal plants and natural compounds that inhibit bacterial quorum sensing (QS), a key virulence factor, offering novel therapeutic strategies beyond antibiotics.
Area of Science:
- Pharmacology and Pharmacognosy
- Microbiology
- Natural Product Chemistry
Background:
- Rising antimicrobial resistance drives the search for alternative treatments.
- Bacterial quorum sensing (QS) regulates virulence factors, making it a promising drug target.
- Phytochemicals from medicinal plants show potential as anti-virulence agents.
Purpose of the Study:
- To review research on plants and natural compounds exhibiting anti-quorum sensing (anti-QS) potential.
- To highlight QS inhibition as a strategy against bacterial pathogenicity.
- To explore phytochemicals as novel anti-infective agents.
Main Methods:
- Literature review of pharmacological and pharmacognostical research.
- Analysis of studies reporting anti-QS activities of plant-derived compounds.
- Identification of phytochemical classes with QS inhibitory properties.
Main Results:
- Medicinal plants contain diverse phytochemicals (phenolics, flavonoids, alkaloids, etc.) with anti-QS capabilities.
- These natural compounds can inhibit bacterial pathogenicity by disrupting QS mechanisms.
- Plant-derived anti-QS agents offer a promising alternative to conventional antibiotics.
Conclusions:
- Medicinal plants are a valuable source of novel anti-QS compounds.
- Targeting QS presents a viable strategy for combating bacterial infections.
- Further research into phytochemicals can lead to new anti-virulence therapies.
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