Patient profiling for success after weight loss surgery (GO Bypass study): An interdisciplinary study protocol

Area of Science:

• Bariatric surgery outcomes
• Obesity research
• Multidisciplinary health

Background:

• Mechanisms explaining weight loss after RYGB and SL are insufficient to account for individual variability.
• Obesity development involves complex biological, behavioral, affective, and contextual factors, influencing treatment success.
• Existing models lack a holistic approach, necessitating integrated explanatory frameworks.

Purpose of the Study:

• To investigate the wide range of individual outcomes following RYGB and SL.
• To develop a multi-dimensional predictive model incorporating biological, psychological, and sociological factors.
• To enhance understanding of factors influencing weight loss variability after bariatric surgery.

Main Methods:

• Prospective study of 55 patients (47 women, 8 men) aged 25-56 with a BMI of 45.8 ± 7.1 kg/m² awaiting RYGB or SL.
• Comprehensive assessment of physiological, psychological, and sociological endpoints pre-surgery and at 1.5, 6, and 18 months post-surgery.
• Inclusion of diverse measures: anthropometrics, genetics, gut microbiota, appetite hormones, psychiatric symptoms, eating disorders, personality traits, sociodemographics, and eating behaviors.

Main Results:

• Data collection across multiple domains including physiological, psychological, and sociological factors.
• Development of a novel multi-dimensional predictive model integrating diverse scientific disciplines.
• Primary endpoint data publication anticipated in 2018.

Conclusions:

• A comprehensive, multi-dimensional approach is crucial for understanding and predicting weight loss variability after bariatric surgery.
• Integrating biological, behavioral, affective, and contextual factors offers a more complete explanatory model.
• This research pioneers a holistic methodology to address individual differences in bariatric surgery outcomes.