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Updated: Feb 7, 2026

Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Iris melanoma presenting as childhood glaucoma.
Briana C Gapsis1, Nichelle A Warren1, Matthew J Nutaitis1
1Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA.
This study details a rare pediatric iris melanoma case, highlighting early detection and treatment with Iodine-125 plaque brachytherapy. Prompt management is crucial for reducing local progression and metastasis risks in pediatric uveal melanoma.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Medical Case Study
Background:
- Iris melanoma is a rare ocular tumor, particularly in pediatric populations.
- Early diagnosis and management are critical for favorable outcomes.
- Pediatric uveal melanoma presents unique challenges in treatment and monitoring.
Observation:
- A 7-year-old female presented with pupillary abnormalities, progressing to iris changes by age 9.
- At 11, she had elevated intraocular pressure and optic nerve cupping due to a pigmented iris lesion invading the angle.
- Trans-corneal fine needle aspirate biopsy confirmed malignant iris melanoma.
Findings:
- The pediatric patient was treated with Iodine-125 plaque brachytherapy for the iris melanoma.
- Management of associated glaucoma required careful consideration of tumor-specific factors.
- Early identification and intervention are key to preventing local tumor progression.
Implications:
- This case underscores the importance of vigilance for rare pediatric ocular tumors.
- Effective treatment strategies for pediatric iris melanoma require a multidisciplinary approach.
- Addressing both the tumor and secondary glaucoma is vital for preserving vision and preventing metastasis.
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