Manipulating Metallogel Properties by Luminogens and Their Applications in Cell Imaging
Arnab Biswas1, Sujay Mukhopadhyay1, Roop Shikha Singh1
1Department of Chemistry, Institute of Science, and Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India.
Abstract:
Manipulating gelation properties of the isomeric zinc-terpyridine complexes C-1 (nongelator) and C-2 (gelator) using three different luminescent dyes, viz., acridine yellow (AY), ethidium bromide (EB), and azido-boron dipyrromethene, have been described. Hybrid gels created by the combination of C-1, C-2, and above-mentioned dyes have been termed complex-luminogen mixed gels (CLMGs). Ensuing CLMGs have been thoroughly characterized by spectral, morphological, and rheological studies. Cytotoxicity measurements and imaging against breast cancer cell line MDA-MB-231 unveiled that three out of the five CLMGs can be effectively used for cell imaging. Interestingly, direct use of the metal-containing hybrid gels for live cell imaging which is a distinctive approach, has been successfully achieved with significantly encouraging results.
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