Impaired oscillometric arterial stiffness parameters in patients with coronary artery ectasia
Alaa Quisi1, Gökhan Alıcı, Samir Allahverdiyev
1Department of Cardiology, University of Health Sciences Adana Numune Training and Research Hospital, Adana. dr.quisi@hotmail.com.
Insights
Patients with coronary artery ectasia (CAE) show impaired aortic elastic properties, specifically higher pulse wave velocity (PWV) and lower augmentation index (AIx). These findings highlight potential cardiovascular risks associated with CAE.
Area of Science:
- Cardiovascular Medicine
- Vascular Biology
- Diagnostic Imaging
Background:
- Coronary artery ectasia (CAE) is a condition affecting the coronary arteries.
- The elastic properties of the aorta are crucial indicators of cardiovascular health.
- Oscillometric methods offer a non-invasive approach to assess aortic stiffness.
Purpose of the Study:
- To investigate aortic elastic properties in patients with isolated coronary artery ectasia (CAE).
- To compare aortic stiffness parameters between patients with CAE, coronary artery disease (CAD), and healthy controls.
- To identify factors associated with CAE using oscillometric measurements.
Main Methods:
- 137 patients were categorized into three groups: CAE (n=51), CAD (n=36), and controls (n=50).
- Aortic stiffness (AS) was assessed using the oscillometric method, measuring pulse wave velocity (PWV) and augmentation index (AIx).
- Statistical analyses, including multinomial logistic regression, were performed to identify associations.
Main Results:
- Patients with CAE exhibited significantly higher mean PWV compared to CAD and control groups (p=0.008).
- The median AIx was significantly lower in the CAE group versus CAD and control groups (p=0.010).
- Gender, hypertension, HDL cholesterol, PWV, and AIx were independently associated with CAE.
Conclusions:
- Oscillometric assessment reveals impaired aortic elastic properties in patients with CAE.
- Elevated PWV and reduced AIx are key indicators of aortic stiffness in CAE.
- These findings underscore the importance of evaluating aortic health in CAE patients.
Objective:
The aim of this study was to investigate the oscillometric measurements of the elastic properties of the aorta in patients with isolated coronary artery ectasia (CAE).
Methods:
This study included 137 patients (92 men and 45 women; mean age: 60.8±11.7 years) who underwent coronary angiography to investigate ischemic heart disease. The patients were divided into 3 groups; the first group consisted of 51 patients with CAE, the second group comprised 36 patients with coronary artery disease (CAD), and the third group was made up of 50 patients with normal coronary arteries. Aortic stiffness (AS) measurements, including pulse wave velocity (PWV) and augmentation index (AIx), were measured using the oscillometric method.
Results:
The mean PWV was significantly higher in the CAE group compared with the CAD and control groups (9.1±2.3 vs. 8.2±1.3 and 8.0±1.6; p=0.008), whereas the median AIx was significantly lower in the CAE group compared with the CAD and control groups (10.0% [-3.0-63.0] vs. 15.5% [-2.0-57.0] and 21.5% [-1.0-45.0]; p=0.010). Multinomial logistic regression analysis demonstrated that gender, hypertension, highdensity lipoprotein cholesterol level, PWV, and AIx were independently associated with CAE.
Conclusion:
The oscillometric elastic properties of the aorta, including PWV and AIx, are impaired in patients with CAE.
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