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Related Experiment Video

Updated: Feb 7, 2026

A Mouse Model for Laser-induced Choroidal Neovascularization
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TYPICAL POLYPOIDAL CHOROIDAL VASCULOPATHY AND POLYPOIDAL CHOROIDAL NEOVASCULARIZATION.

Jun Won Jang1, Jong Min Kim, Se Woong Kang

  • 1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Retina (Philadelphia, Pa.)
|July 20, 2018
PubMed
Summary

Typical polypoidal choroidal vasculopathy (T-PCV) and polypoidal choroidal neovascularization (P-CNV) show distinct visual outcomes and treatment responses. Differentiating these subtypes of polypoidal choroidal vasculopathy is crucial for understanding disease progression and prognosis.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Choroidal Vasculopathy

Background:

  • Polypoidal choroidal vasculopathy (PCV) is a significant cause of vision loss.
  • PCV is often classified into typical PCV (T-PCV) and polypoidal CNV (P-CNV).
  • Understanding the differences between these subtypes is essential for effective management.

Purpose of the Study:

  • To compare the clinical characteristics and visual outcomes of T-PCV and P-CNV.
  • To evaluate the significance of classifying PCV into these two subtypes.
  • To assess treatment responses in T-PCV versus P-CNV.

Main Methods:

  • Retrospective review of 77 patients with PCV followed for over 12 months.
  • Classification of patients into T-PCV (n=36) and P-CNV (n=41) groups based on specific clinical features.
  • Comparison of angiographic, tomographic, and visual acuity data between the groups.

Main Results:

  • T-PCV patients had significantly better visual acuity at baseline and final visit compared to P-CNV patients.
  • A trend towards higher response rates to anti-VEGF treatment was observed in the T-PCV group (47.2% vs 26.8%).
  • Subfoveal fibrosis was significantly more common in the P-CNV group (39.0%) than in the T-PCV group (11.1%) at the final visit.

Conclusions:

  • T-PCV and P-CNV exhibit distinct angiographic and tomographic features.
  • These subtypes differ in their visual outcomes and response to anti-VEGF therapy.
  • Classification of PCV subtypes holds prognostic value and aids in understanding pathogenesis.