The role of miR-144/GSPT1 axis in gastric cancer
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Updated: Feb 7, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
1Department of General Surgery, The Fourth Affiliated Hospital of Baotou Medical College, Baotou, China. 2311030163@qq.com.
Objective:
To investigate the potential effects of miR-144/GSPT1 axis on the development of gastric cancer.
Patients And Methods:
The expressions of GSPT1 (G1 to S Phase Transition 1) and miR-144 were detected in gastric cancer tissues and the adjacent normal tissues. We also explored the levels of GSPT1 and miR-144 in both normal gastric cell line (GES-1) and gastric cells (SGC7901). Luciferase assay was conducted to evaluate the interaction between miR-144 and GSPT1. The effects of the miR-144/GSPT1 axis on SGC7901 cells were determined via investigating cell proliferation, invasion and metastasis.
Results:
miR-144 was found to be down-regulated in gastric cancer tissues while GSPT1 expression level was markedly increased. Bioinformatics analysis showed that GSPT1 was a direct target of miR-144. Luciferase assays confirmed our hypothesis. The subsequent experiments showed that miR-144 could promote cell proliferation, invasion and migration in gastric cancer cells via inhibiting GSPT1.
Conclusions:
We showed that miR-144/GSPT1 axis could be a potential therapeutic target in treatment of gastric cancer.
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