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Updated: Feb 7, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
Published on: March 2, 2020
Low- q Bicelles Are Mixed Micelles
Tracy A Caldwell1, Svetlana Baoukina2, Ashton T Brock1
1Department of Chemistry , University of Virginia , Charlottesville , Virginia 22904 , United States.
Abstract:
Bicelles are used in many membrane protein studies because they are thought to be more bilayer-like than micelles. We investigated the properties of "isotropic" bicelles by small-angle neutron scattering, small-angle X-ray scattering, fluorescence anisotropy, and molecular dynamics. All data suggest that bicelles with a q value below 1 deviate from the classic bicelle that contains lipids in the core and detergent in the rim. Thus not all isotropic bicelles are bilayer-like.
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