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Published on: June 29, 2015
Astrocyte activation and reactive gliosis-A new target in stroke?
Milos Pekny1, Ulrika Wilhelmsson2, Turgut Tatlisumak3
1Center for Brain Repair, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Box 440, 40530 Gothenburg, Sweden; Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia; University of Newcastle, Newcastle, NSW, Australia.
Abstract:
Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes. Astrocyte activation and reactive gliosis in the acute stage of stroke limit the tissue damage and contribute to the restoration of homeostasis. Astrocytes also control many aspects of neural plasticity that is the basis for functional recovery. Here, we discuss the concept of intermediate filaments (nanofilaments) and the complement system as two handles on the astrocyte responses to injury that both present attractive opportunities for novel treatment strategies modulating astrocyte functions and reactive gliosis.
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