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Deep brain stimulation does not enhance neuroinflammation in multiple system atrophy.
Miguel Lopez-Cuina1, Pierre-Olivier Fernagut2, Marie-Hélène Canron1
1Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
Neurobiology of Disease
|July 21, 2018
Summary
Multiple system atrophy (MSA) with a Parkinson's-like presentation shows distinct alpha-synuclein pathology. Deep brain stimulation (DBS) does not worsen MSA neuroinflammation but may be linked to disease progression.
Area of Science:
- Neuroscience
- Neuropathology
- Neurodegenerative Diseases
Background:
- Multiple system atrophy (MSA) can mimic Parkinson's disease (PD), leading to misdiagnosis.
- Deep brain stimulation (DBS), effective for PD, is often ineffective or detrimental in MSA patients.
Purpose of the Study:
- To investigate neuropathological differences between MSA patients treated with DBS and typical MSA cases.
- To determine if these differences explain the benign clinical course in some MSA patients and rapid decline after DBS.
Main Methods:
- Post-mortem neuropathological assessment of brain regions (subthalamic nucleus, globus pallidus, thalamus, putamen).
- Comparison of five MSA patients who received DBS with nine typical MSA cases.
- Analysis of neuroinflammation and alpha-synuclein pathology.
Main Results:
- No significant differences in neuroinflammatory profiles between DBS-treated and typical MSA groups.
- DBS-treated MSA patients showed a higher proportion of alpha-synuclein inclusions in the putamen.
- Neuron survival rates were similar between the groups.
Conclusions:
- Deep brain stimulation (DBS) does not appear to induce neuroinflammation in multiple system atrophy (MSA).
- Increased alpha-synuclein inclusions in the putamen may correlate with a milder, "PD-like" phenotype and slower progression in MSA.
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