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Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model

Yasushi Shibue1, Soichiro Kimura2, Chiaki Kajiwara2

  • 1Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16, Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; First Department of Medicine, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.

Microbes and Infection
|July 21, 2018
PubMed

Insights

Interleukin-17A deficiency increases mortality in community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia. IL-17A-knockout mice showed higher mortality and neutrophilic inflammation, despite similar bacterial loads.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pulmonology

Background:

  • Interleukin (IL)-17 is a critical Th17 cytokine implicated in various diseases.
  • Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) causes severe pneumonia.
  • The specific role of IL-17 in CA-MRSA pneumonia remains unclear.

Purpose of the Study:

  • To investigate the role of IL-17 in a murine model of CA-MRSA pneumonia.
  • To determine the impact of IL-17 deficiency on infection outcomes and host response.

Main Methods:

  • Utilized a CA-MRSA pneumonia animal model.
  • Compared outcomes in wild-type, IL-17A-knockout, and IL-17A/F-double-knockout mice.
  • Assessed mortality, bacterial counts, cytokine levels (IL-17F, G-CSF), and neutrophil infiltration.

Main Results:

  • IL-17A-knockout mice exhibited higher mortality at an earlier stage compared to wild-type and IL-17A/F-knockout mice.
  • No significant differences in intrapulmonary bacterial counts were observed across groups.
  • IL-17A deficiency led to increased IL-17F and G-CSF levels, with elevated neutrophil counts in bronchoalveolar lavage fluid.

Conclusions:

  • IL-17A plays a protective role in CA-MRSA pneumonia, with its deficiency exacerbating disease severity.
  • Increased G-CSF expression and neutrophilic inflammation are associated with IL-17A deficiency in this model.
  • Further research into IL-17-targeted therapies for CA-MRSA infections is warranted.
Keywords:
IL-17MRSAPneumonia

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