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Modulation of antibiotic effect by Fe2(MoO4)3 microstrutures.

T S Freitas1, F S Oliveira1, R P Cruz1

  • 1Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, CEP 63105-000 Crato, CE, Brazil.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|July 21, 2018
PubMed
Summary

Iron molybdate (Fe2(MoO4)3) microstructures show no direct antibacterial effect. However, they antagonize common antibiotics, increasing their minimum inhibitory concentration (MIC) due to pro-oxidative properties.

Keywords:
Antibacterial activityFerric molybdateFree radicalsHydrothermal synthesisModulatory-antibiotic activity

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Microbiology

Background:

  • Metallic oxides are explored for antimicrobial applications.
  • Understanding the interaction between novel materials and antibiotics is crucial for drug development.
  • Iron molybdate (Fe2(MoO4)3) microstructures were synthesized hydrothermally.

Purpose of the Study:

  • To investigate the antibacterial activity of Fe2(MoO4)3 microstructures.
  • To evaluate the modulatory effect of Fe2(MoO4)3 on existing antibiotic activity.
  • To characterize the synthesized Fe2(MoO4)3 material.

Main Methods:

  • Hydrothermal synthesis of Fe2(MoO4)3 without surfactants.
  • Material characterization using X-ray diffraction (XRD), Raman spectroscopy, and scanning electron microscopy (SEM).
  • Antibacterial assays against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus using microdilution method, evaluating both direct and antibiotic-modulatory effects.

Main Results:

  • Fe2(MoO4)3 crystallized in a monoclinic structure with a ball-of-yarn morphology.
  • Fe2(MoO4)3 exhibited no significant direct antibacterial activity (MIC ≥ 1024 μg/mL).
  • Fe2(MoO4)3 showed an antagonistic effect when combined with gentamicin, norfloxacin, and imipenem, increasing their MIC values.

Conclusions:

  • The antagonistic effect is attributed to the pro-oxidative properties of Fe2(MoO4)3, leading to increased free radical production.
  • Potential coordination of iron with antibiotics may reduce antibiotic efficacy.
  • Fe2(MoO4)3 is unsuitable for direct clinical antimicrobial use or as an adjunct therapy with antibiotics.