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Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
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Location and Threshold of Electrical Cortical Stimulation for Functional Brain Mapping
Aya Kanno1, Rei Enatsu1, Satoshi Ookawa1
1Department of Neurosurgery, Sapporo Medical University, Sapporo, Japan.
World Neurosurgery
|July 21, 2018
Summary
Electrical cortical stimulation thresholds reveal that positive and sensory responses require lower intensities than negative and motor responses, aiding functional brain mapping. This study clarifies stimulation thresholds for precise brain area identification.
Area of Science:
- Neuroscience
- Neurosurgery
- Epilepsy Research
Background:
- Functional localization by electrical stimulation has varying thresholds.
- Accurate thresholds are crucial for effective cortical mapping.
Purpose of the Study:
- To determine the electrical stimulation threshold for functional mapping.
- To clarify controversial thresholds in cortical stimulation studies.
Main Methods:
- Analysis of 17 epilepsy patients undergoing 50-Hz electrical cortical stimulation.
- Evaluation of induced symptoms and stimulation thresholds for responses.
Main Results:
- Motor and sensory responses mapped to specific cortical areas.
- Negative responses (aphasia, motor deficits, spatial impairment) observed with stimulation.
- Lower thresholds for positive/sensory responses compared to negative/motor responses (P < 0.01).
Conclusions:
- Positive and sensory brain responses are elicited at lower stimulation intensities.
- Findings offer a practical guide for functional mapping and a hierarchical processing concept.
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