Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

33.1K
Overview
33.1K
Reactivity of Enols01:18

Reactivity of Enols

4.1K
Enols are a class of compounds where a hydroxyl group is attached to a carbon–carbon double bond, which implies that it is a vinyl alcohol. A carbonyl compound with an α hydrogen undergoes keto–enol tautomerism and remains in equilibrium with its tautomer, the enol form. Usually, the keto tautomer is present in a higher concentration than the enol tautomer due to the higher bond energy of C=O compared to C=C. Moreover, the direction of the keto–enol equilibrium is...
4.1K
Reactivity of Enolate Ions01:23

Reactivity of Enolate Ions

3.4K
Enolate ions are formed by the acid–base reaction of a carbonyl compound with a base. This leads to deprotonation of the α hydrogen atom, leading to a resonance-stabilized enolate ion where one of the contributing structures is an oxyanion, which imparts additional stability. Therefore, the proton on the α carbon is more acidic in nature than that of other sp3-hybridized C–H bonds but less acidic than those in O–H bonds where the negative charge in the conjugate...
3.4K
Radical Reactivity: Overview01:11

Radical Reactivity: Overview

2.8K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.8K
Radical Reactivity: Nucleophilic Radicals01:16

Radical Reactivity: Nucleophilic Radicals

2.7K
Radicals adjacent to electron-donating groups are called nucleophilic radicals. These radicals readily react with electrophilic alkenes. The SOMO–LUMO interactions are the driving force for the reaction, where the high-energy SOMO of the electron-rich, nucleophilic radicals interacts with the low-energy LUMO of the electron-deficient, electrophilic alkenes. Such SOMO–LUMO interactions are the basis of reactive radical traps, affecting the selectivity in radical reactions. For...
2.7K
Radical Reactivity: Intramolecular vs Intermolecular01:33

Radical Reactivity: Intramolecular vs Intermolecular

2.2K
Radical reactions can occur either intermolecularly or intramolecularly. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene or vice versa. In such reactions, the radical and generally the alkene, which is also called the radical trap, are two different molecules. Additionally, for such intermolecular reactions to occur, the radical trap must be active, present in an excess concentration, and the radical starting material must have a weak...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A national programme of bivalent prefusion F vaccination in pregnancy and protection against respiratory syncytial virus hospitalisation in infants until age 6 months in the UK: a multicentre, prospective, test-negative, case-control study.

The Lancet. Child & adolescent health·2026
Same author

Dexamethasone for acute wheeze exacerbations in children: have the associated risks been fully considered?

Archives of disease in childhood·2026
Same author

Refreshing the paediatric emergency medicine research priorities across the UK and Ireland.

Emergency medicine journal : EMJ·2026
Same author

Incidence of herpes simplex infection among febrile infants under 3 months of age: evidence from two multisite cohorts.

Archives of disease in childhood·2026
Same author

Maternal perspectives on the RSV vaccine (Abrysvo): a thematic analysis of survey findings from the first season of implementation in England and Scotland.

Archives of disease in childhood·2026
Same author

A single-centre randomised, feasibility study using point-of-care (POC) testing for respiratory viruses to direct oral corticosteroids use in preschool-aged children with acute wheeze: a protocol.

Pilot and feasibility studies·2026
Same journal

Implementing a 'special educational needs transition checklist' for young people with complex disability.

Archives of disease in childhood. Education and practice edition·2026
Same journal

Delivery room respiratory care: a quality improvement project to reduce preterm intubations.

Archives of disease in childhood. Education and practice edition·2026
Same journal

Neonate with 'rocker-bottom' feet: what to do when it is not Edwards syndrome.

Archives of disease in childhood. Education and practice edition·2026
Same journal

Breaking the heat: managing steroid refractory warm autoimmune haemolytic anaemia.

Archives of disease in childhood. Education and practice edition·2026
Same journal

Peripheral precocious puberty due to inadvertent exposure to topical oestradiol gel and review of the literature.

Archives of disease in childhood. Education and practice edition·2026
Same journal

Noisy breathing and faltering growth in a 2-month-old infant: stertor, not stridor.

Archives of disease in childhood. Education and practice edition·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

16.9K

How to use C-reactive protein.

Emma M Dyer1, Thomas Waterfield2, Hannah Baynes3

  • 1Kings College Hospital, London, UK.

Archives of Disease in Childhood. Education and Practice Edition
|July 21, 2018
PubMed
Summary
This summary is machine-generated.

C-reactive protein (CRP) testing in infants with fever can guide antibiotic use and hospital admission decisions. This review examines evidence to optimize CRP

Keywords:
biochemistrygeneral paediatricsinfectious diseasesneonatology

More Related Videos

Reactivation of Demembranated Cell Models in Chlamydomonas reinhardtii
03:37

Reactivation of Demembranated Cell Models in Chlamydomonas reinhardtii

Published on: May 6, 2022

2.6K
Preparation and Reactivity of Gasless Nanostructured Energetic Materials
09:50

Preparation and Reactivity of Gasless Nanostructured Energetic Materials

Published on: April 2, 2015

10.7K

Related Experiment Videos

Last Updated: Feb 7, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

16.9K
Reactivation of Demembranated Cell Models in Chlamydomonas reinhardtii
03:37

Reactivation of Demembranated Cell Models in Chlamydomonas reinhardtii

Published on: May 6, 2022

2.6K
Preparation and Reactivity of Gasless Nanostructured Energetic Materials
09:50

Preparation and Reactivity of Gasless Nanostructured Energetic Materials

Published on: April 2, 2015

10.7K

Area of Science:

  • Pediatric Emergency Medicine
  • Clinical Biochemistry
  • Infectious Disease Management

Background:

  • Fever in infants necessitates careful evaluation for serious infection.
  • C-reactive protein (CRP) is a widely used inflammatory marker.
  • The clinical utility of CRP in pediatric fever management is debated.

Purpose of the Study:

  • To review the current evidence on C-reactive protein (CRP) use in febrile infants.
  • To determine how CRP levels influence antibiotic therapy decisions.
  • To assess the impact of CRP on decisions regarding patient admission versus discharge.

Main Methods:

  • Literature review of studies evaluating CRP in pediatric fever.
  • Analysis of clinical guidelines and expert opinions.
  • Case vignette illustrating CRP interpretation in a 3-month-old infant.

Main Results:

  • CRP levels can aid in differentiating bacterial from viral infections.
  • Elevated CRP may support the initiation of antibiotic treatment.
  • CRP values, alongside clinical assessment, inform admission and discharge strategies.

Conclusions:

  • CRP is a valuable tool when integrated with clinical judgment in febrile infants.
  • Evidence supports using CRP to guide antibiotic stewardship.
  • Optimizing CRP interpretation enhances clinical decision-making for pediatric fever.