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Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure

Leon J DeLalio1,2, Alexander S Keller1,2, Jiwang Chen3

  • 1From the Robert M. Berne Cardiovascular Research Center (L.J.D., A.S.K., H.R.A.-P., T.C.S.K., S.R.J., R.B.W., M.E.G., S.A.M., A.K.B., B.E.I.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|July 21, 2018
PubMed
Summary

Caveolin-1 (Cav1) in vascular smooth muscle cells (VSMCs) is crucial for pannexin-1 (Panx1) channel function, regulating blood pressure through adrenergic vasoconstriction. Disrupting this interaction impairs blood pressure homeostasis.

Keywords:
Pannexin 1adrenergic agentsblood pressurecaveolaemuscle, smooth

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