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Investigating the Association between Chronic Kidney Disease and Ischaemic Stroke from a Health Examination Database
Chao Ou-Yang1, Theresa Lalita Handaruputri1, Han-Cheng Wang2,3,4
1Department of Industrial Management, National Taiwan University of Science and Technology, Taipei, Taiwan.
Insights
Chronic kidney disease (CKD) significantly increases the risk of ischaemic stroke, especially in younger individuals. Shared risk factors like diabetes and hypertension exacerbate this danger, highlighting the need for targeted prevention strategies.
Area of Science:
- Nephrology
- Neurology
- Epidemiology
Background:
- Stroke is a leading cause of death, with ischaemic stroke being the most prevalent type.
- Chronic kidney disease (CKD) is a major mortality determinant and shares cardiovascular risk factors with stroke.
Purpose of the Study:
- To investigate shared risk factors between CKD and ischaemic stroke.
- To analyze the association between CKD and ischaemic stroke in a Taiwanese population.
Main Methods:
- Utilized a health examination database from a Taiwanese medical center.
- Employed generalized linear regression and Mantel-Haenszel tests for statistical analysis.
- Conducted a prevalence rate study to compare ischaemic stroke incidence between CKD and non-CKD subjects.
Main Results:
- Subjects with CKD exhibited a higher prevalence of ischaemic stroke compared to those without CKD.
- Diabetes, hypertension, hypertriglyceridemia, and hypercholesterolemia were identified as significant risk factors for ischaemic stroke in CKD patients.
- An inverse association of the odds ratio for ischaemic stroke was observed between CKD and non-CKD patients, particularly in younger demographics.
Conclusions:
- CKD is a significant risk factor for ischaemic stroke, with common cardiovascular conditions amplifying the risk.
- Younger individuals with CKD require heightened awareness and proactive prevention measures against ischaemic stroke.
Abstract:
Stroke has become one of the leading causes of death, with ischaemic stroke as the most common type of stroke occurrence compared to haemorrhagic stroke. Chronic kidney disease(CKD), another important cause of death, shares several traditional cardiovascular riskfactors with ischaemic stroke. Therefore, it is important to examine the existence of shared risk factors in the association between CKD and ischaemic stroke. This study used a health examination database from a medical centre in Taiwan. A generalized linear regression analysis was used to determine the association between CKD and ischaemic stroke. The Maentel-Haenszel test was performed to analyse the effect of possible confounding factors on the association between CKD and ischaemic stroke. A prevalence rate study showed that more subjects with CKD suffered from ischaemic stroke than subjects without CKD. Diabetes, hypertension, hypertriglyceridemia, and hypercholesterolemia were associated with increased risks of ischaemic stroke in CKD subjects. There was an inverse association of the odds ratio of ischaemic stroke between CKD and non-CKD patients, which implied that younger subjects with CKD should be made aware of ischaemic stroke prevention.
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